Hello,
    I will help if I can. What storage type are you using for settings (this is the site_settings_storage setting)? The default is file based storage. If you are using that does the directory defined in the hastymail2.conf file (called settings_path) have the correct permissions for write access? If you are using a database to store settings there is a db_debug option in the hastymail2.conf file you can use to get more information about the problem.

Hope that helps,
Jason